Fexofenadine blocks one type of peripheral receptor for histamine (the H1 receptor) and thus prevents activation of H1 receptor-containing cells by histamine (Histamine is released from histamine-storing cells (mast cells) and then attaches to other cells that have receptors for histamine. The attachment of the histamine to the receptors causes the cell to be "activated," releasing other chemicals that produce the effects that we associate with allergy, e.g., sneezing.) and the allergic symptoms produced by it.
Pharmacokinetics
Absorption : Rapidly absorbed after oral administration.
Distribution : Widely distributed in the body. 60-70% bound to the plasma proteins.
On Set of Action
14 hrs
Half Life
14.4 hrs
Adverse Effects
1. Headache
2. Dizziness
3. Drowsiness
4. Back pain
5. Cough
6. Nausea
ContraIndications
Contraindicated in patients with hypersensitivity to the drug or other ingredients
Special Precautions
1. Renal dysfunction
2. Any work which require mental alertness like driving and machine operations
Pregnancy
Use with caution
Breast Feeding
Use with caution
Elderly
Use with caution
Children
Use with caution
Interactions
An increase in the level of fexofenadine in plasma of 2-times was observed after co-administration of erythromycin or ketoconazole.
Indications
1. Hay fever
2. Runny nose
3. Sneezing
4. Tearing eyes
5. Hives
Dosage
Oral-
Adult and Children (12yrs)-
Allergic Rhinitis : 120mg once daily
Allergic Skin Conditions : 180mg once daily
Others
Schedule-NULL
Storage
Store at room temperature and away from excess heat and moisture
Over Dose
Give symptomatic and supportive treatment. |
