Sertraline blocks the re-uptake of neurotransmitter Serotonin from the synapse in to the presynaptic nerve terminal in the CNS. This will prolong the action of Serotonin (5HT) and it is useful in the treatment of depression.

Pharmacokinetics
Absorption : Sertraline is well absorbed after oral administration.
Distribution  : It is distributed in the body in protein bound form.

On Set of Action
1 week

Half Life
26 hours

Adverse Effects
1. Insomnia
2. Nausea
3. Diarrhoea
4. Headache
5. Fatigue
6. Dizziness
7. Tremor
8. Somnolence
9. Dry mouth
10. Anorexia

ContraIndications
1. Hypersensitivity to Sertraline
2. Patient on MAOI (Monoamine oxidase inhibitor) therapy

Special Precautions
1. Hepatic impairment
2. Renal impairment
3. Epilepsy
4. Hypomania
5. Metabolic disorder
6. Alcoholics
7. Patient on MAOI therapy (Discontinue the MAO inhibitor at least 2 weeks before Sertraline is started)
8. Use cautiously in patient at risk for suicide
9. Use caution while driving vehicle, operating machine and activities requiring mental

Pregnancy
Use with caution

Breast Feeding
Use with caution

Elderly
Use with caution

Children
Contraindicated

NEONATES
Contraindicated

Indications
1. Panic disorder
2. Post traumatic stress disorder
3. Depression
4. Obsessive compulsive disorder

Dosage
Adult
Panic disorder, Post traumatic stress disorder: Initial dose: 25 mg / day dose can be gradually increased every week if sufficient response does not occurs.
Maximum dose: 200 mg / day
Depression, Obsessive compulsive disorder: Initial dose: 50 mg / day dose can be gradually increased every week if sufficient response does not occur.
Maximum dose: 200 mg / day